Recruitment of p300/CBP in p53-Dependent Signal Pathways

Recruitment of p300/CBP in p53-Dependent Signal Pathways

The products of the p53 and CBP/p300 genes have been individually implicated in control of cell growth and regulation of transcription. p53 is known to act as a positive and negative regulator of gene expression. Here we show that p53, in both wild-type and mutant conformation, forms a specific protein complex with p300. However, in its wild-type but not mutant conformation, p53 inhibits a prom...

p53-Dependent and -Independent Pathways

Focal adhesion kinase and p53 signal transduction pathways in cancer.

Human cancer is characterized by a process of tumor cell motility, invasion, and metastasis. One of the critical tyrosine kinases that is linked to these processes of tumor invasion and survival is the Focal Adhesion Kinase (FAK). Our laboratory was the first to isolate FAK from human tumors, and we had demonstrated that FAK mRNA was up-regulated in invasive and metastatic human breast and colo...

Apoptotic Cell Death in Sepsis p53-Dependent and -Independent Pathways

Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells.

Apoptosis may involve p53-dependent and -independent pathways. Results presented here suggest a possible cooperation between these two types of pathways. M1/2 is a p53-nonproducer subclone that may undergo either a p53-independent apoptosis following growth factor deprivation or a p53-dependent apoptosis following reconstitution of wild-type p53 expression. The p53-independent apoptosis in thes...